Undergraduate Skin Cancer Prevention Trial

The proposed study is a Multiphase Optimization Strategy (MOST) that uses factorialexperiments to evaluate individual and combined effects of intervention components toimprove intervention efficiency. The study team will use MOST to test an interventionthat has the potential to eliminate sunburn in higher‐risk young people during thehighest risk times of the year. The study will enroll a total of 528 undergraduatestudents (>18 years) total in Years 1 through 4 of the award period.After students provide informed consent, they will complete a baseline assessment via theREDCap data capture system on their sunburn occurrence, sun protection behaviors, andtanning behaviors. Following the baseline assessment, students will be randomized to eachgroup using computer‐generated randomly permuted blocks, stratified by sex andunintentional/intentional tanning. There are three intervention components that arecandidates for inclusion in the optimized RISE‐UP intervention: 1) UV Photo, 2) ActionPlan, and 3) MC1R Testing. All conditions will receive education on skin cancer andstrategies to prevention skin cancer, including sun protection strategies and avoidanceof intentional and unintentional tanning.The optimized intervention will take place approximately one month after the baselineassessment. Participants allocated to receive the UV photo will receive a printout photoof their face in visible light and UV light from the VISIA Complexion Analysis system.Participants who receive the action plan will complete an individualized sun protectionand tanning plan for situations in which they receive ultraviolet radiation (UVR)exposure. Participants who are allocated to receive MC1R testing will be asked to providea saliva sample. Once sequenced, participants will receive their results that addressesboth their personal and population risk level.One month after the optimized intervention, participants will be asked to completeanother assessment. Participants will also be asked to complete an additional follow‐upassessment 3 months later and at 15‐months post‐intervention. In total, participants willbe asked to complete 4 separate assessments. Participants will also be asked to wear aUVR monitoring device for 7‐day periods immediately after each of the 4 assessments.