NEM® + BIOCURC® Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women

Moderate exercise can induce discomfort in joints when done infrequently or when done too intensely or for too long a period. This discomfort is often realized as either pain or stiffness in the joint that was the focus of the exercise. For example, one's knees will hurt after jogging for several miles, particularly if jogging for the first time. This study is intended to evaluate whether the combination of NEM® brand eggshell membrane and BIOCURC® brand bioavailable curcumin can alleviate joint pain or stiffness, either directly following exercise or 12 hours post‐exercise versus placebo. The study will also evaluate the combination's effect, on cartilage turnover via the cartilage degradation biomarker c‐terminal cross‐linked telopeptide of type II collagen (CTX‐II). Participants will perform a minimum of 50 steps per leg utilizing an aerobics step at the clinical site. They will follow this exercise regimen on alternating days for 2 consecutive weeks. Changes in pain & stiffness (immediate & 12‐hour) will be compared to both baseline and to the placebo group. Urine samples will also be collected at baseline and at the end of Week 1 & Week 2. The change in CTX‐II from baseline will be compared to the placebo group.