A prospective, multicenter, randomized, parallel controlled, subject and evaluator blind, non-inferior clinical trial evaluating the efficacy and safety of injectable tissue matrix fillers for the correction of nasolabial wrinkles

INTERVENTION: Test Group:Tissue matri Xfiller for injection;Control Group:Collagen implants; CONDITION: Nasolabial wrinkles PRIMARY OUTCOME: Efficiency rate; SECONDARY OUTCOME: The efficiency of wrinkle correction;The improvement rate of the overall beauty effect;Subject satisfaction; INCLUSION CRITERIA: 1. Aged >= 18 years old, gender unlimited; 2. Subjects who are willing to correct nasolabial wrinkles; 3. According to the blind evaluator, the nasolabial wrinkle Severity Rating Scale (WSRS) was moderate or severe degree (level 3 on both sides or level 4 on both sides); 4. Be able to tolerate mild pain; 5. Subject has reasonable expectations, understands and complies with study procedures and all visit schedules; 6. Subjects who voluntarily decided to participate in the study and signed informed consent.