Efficacy and complication of Duloxetine in attention deficeit –hyperactivity disorder (ADHD) and comparison with Ritalin

INTERVENTION: Control group: according to Ritalin dosage 0.4‐1.3 mg/kg, Ritalin 1 capsule for the first week (1/2 in the morning and 1/2 at noon), 2 capsule for the second week (1 capsule in the morning and 1 capsule at noon); if the weight of patient is more than 30 kg, 3 capsule will be daily prescribed for the third week (1 capsule in the morning and 1 capsule at noon and 1 capsule in the afternoon) Intervention 1: Intervention group: Duloxetine 1/4 capsule in the first week, 1/2 capsule in second week, 3/4 capsule in third week and 1 capsule in fourth week. Intervention 2: Control group: according to Ritalin dosage 0.4‐1.3 mg/kg, Ritalin 1 capsule for the first week (1/2 in the morning and 1/2 at noon), 2 capsule for the second week (1 capsule in the morning and 1 capsule at noon); if the weight of patient is more than 30 kg, 3 capsule will be daily prescribed for the third week (1 capsule in the morning and 1 capsule at noon and 1 capsule in the afternoon). Intervention group: Duloxetine 1/4 capsule in the first week, 1/2 capsule in second week, 3/4 capsule in third week and 1 capsule in fourth week Treatment ‐ Drugs CONDITION: attention deficiency hyperactivity disorder. ; Disturbance of activity and attention Disturbance of activity and attention PRIMARY OUTCOME: Attention deficiency hyperactivity disorder. Timepoint: Baseline, 2, 4, 6, 8 weeks after treatment. Method of measurement: CANERS test for parents (summerized and edited format) and ADHD rating scale for parents and teacher. SECONDARY OUTCOME: Drugs side effects. Timepoint: Baseline, 2,4,6,8 weeks after treatment. Method of measurement: side effect questionnaire. INCLUSION CRITERIA: INCLUSION CRITERIA: diagnostic criteria based on DSM IV for children with ADHD, age range 11‐18, no consumption of any effective psychological drugs in past two week Exclusion criteria: mental retardation, any other psychological disorders except for ODD, history of allergy to Duloxetine, serious medical conditions such as heart disease, uncontrolled convulsive disorder, systolic pressure upper than 125 mmhg or resting pulse less than 60 or more than 115 bit/m