A comparison of azithromycin and ofloxacin in the treatment of typhoid in adult patients in Laos

INTERVENTION: A randomised, open clinical trial with random allocation to three days ofloxacin or three days azithromycin. Please note that the anticipated end date has been extended to 31st December 2008. CONDITION: Typhoid fever ; Infections and Infestations ; Typhoid fever PRIMARY OUTCOME: The primary outcome measures are fever clearance, cure rate, relapse rate and S. typhi stool carriage rate. SECONDARY OUTCOME: No secondary outcome measures INCLUSION CRITERIA: 1. Adult (more than or equal to 15 years, either sex) non‐pregnant patients with suspected or blood culture proven typhoid 2. Fever more than 37.5 °C 3. Informed written consent to the study 4. Able to stay in hospital for seven days 5. Able to take oral medication 6. Body weight more than 40 kg 7. Likely to be able to complete six months follow up 8. None of the exclusion criteria