From pharmaceutical standardizing to clinical research: 20 years of experience with fifty-millesimal dilutions

Twenty years ago we began to standardize the procedures of preparation and use of fifty-millesimal dilutions (LM or Q) according to indications in the 6th edition of Hahnemann’s Organon. This article describes the main stages in standardization as well as our teaching and research experience on Organon 6th edition. With the use of standardized LM dilutions we observed a lower incidence of homeopathic aggravation than with our earlier experience with non standardized preparations. Organon.modus, a clinical-pharmaceutical protocol derived from the standardization was adequate for the teaching of homeopathy at Faculty of Medicine of Jundiai (São Paulo), the first Brazilian medical school with a graduate course on homeopathy. A randomized double-blind trial comparing individualized homeopathic medicines prescribed in LM dilutions and fluoxetine showed the former not be inferior to the latter in the treatment of moderate-to-severe depression. Protocol Organon.modus showed to be adequate to graduate-level teaching of homeopathy and efficient in a controlled clinical trial, favoring its use as common denominator between the art of healing and medical science.