Regulation of Endogenous Glucose Production by Brain Insulin Action

Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2013
It is well known that the hormone insulin lowers blood glucose in part by acting directly on the liver and reducing hepatic glucose production. Animal studies have shown that the hormone insulin can act on the brain to indirectly lower glucose production by the liver. We aim to test whether this is true in humans by giving insulin intranasally. It has previously been shown that a nasal spray can deliver insulin directly to the brain without affecting circulating insulin concentration.
Epistemonikos ID: 119288e60e9233e830488bbe7a85a850d2e23385
First added on: May 11, 2024