ACL-GAIN trial

Authors
Category Primary study
Registry of TrialsOverview of Medical Research in the Netherlands
Year 2025
INTERVENTION: Anterolateral genicular nerve block using ropivacaine CONDITION: ; Anterior Cruciate Ligament tear, Anterolateral Corner Injury Ruptured Anterior Cruciate Ligament 10005944 PRIMARY OUTCOME: The primary outcome is the Numeric Rating Scale (NRS) pain score during movement at 2 hours postoperatively SECONDARY OUTCOME: Secondary outcomes include cumulative opioid consumption, use of rescue analgesics, patient‐reported outcomes (VAS‐pain, IKDC‐subjective, Tegner, Lysholm, ACL‐RSI) at si Xweeks, and incidence of adverse events. Statistical analyses include mixed‐effects models to compare outcomes between groups while adjusting for baseline variables. INCLUSION CRITERIA:
‐Clinical indication and willingness to undergo combined ACL and anterolateral corner reconstruction‐(Sub)total primary ACL tear on physical examination and MRI, with or without concomitant meniscal injury and/or cartilage injury and/or partial concomitant knee ligament injury not requiring surgery‐Age 16 years and older ‐Preinjury Tegner score 5 and desire to return to preinjury level
Epistemonikos ID: 10c2c9807aa1e2644cc4b8f40a238f94b815ff3f
First added on: Apr 24, 2026