Endoscopic Application of Hemostatic Drug Powder in Lower Gastrointestinal Bleeding: a Pilot Study

This single‐center randomized controlled study was conducted at our hospital and wasapproved by the hospital's Institutional Review Board (A‐BR‐115‐031). Patients withconfirmed LGIB were recruited.This clinical trial will enroll patients at National Cheng Kung University Hospital. Allpatients who are hospitalized for lower gastrointestinal bleeding and undergo colonoscopywill be invited to participate. This study uses random allocation, with one Interventiongroup and one Standard group. Both groups will receive standard endoscopic hemostasis.All the enrolled patients underwent standard endoscopic hemostasis by local injection ofdiluted epinephrine combined with heater probe coagulation, hemoclipping, and/or bandligation. Afterward, patients in the Intervention group will receive local administrationof 1.5 g of tranexamic acid and 3 g of sucralfate. Following the endoscopic procedure,patients will be directly observed for 5 minutes to confirm successful hemostasis. Allpatients will be followed for 28 days to assess the occurrence of post‐proceduralrebleeding.