Clinical Efficacy Evaluation of Chaizhi Hewei Decoction in the Treatment of Non-Erosive Reflux Disease With Liver-Stomach Disharmony Syndrome

This study focuses on patients with NERD (gastroesophageal reflux disease) andliver‐gallbladder disharmony syndrome as its research subjects. It conducts a randomized,double‐blind, placebo‐controlled clinical trial to evaluate the efficacy and safety ofthe Chai Zhi He Wei formula in terms of symptom improvement, quality of life, and adversereactions. On one hand, this research aims to enhance the level of evidence‐basedmedicine for TCM syndrome differentiation and treatment of NERD. On the other hand, itseeks to reduce the dosage of PPIs (proton pump inhibitors) or discontinue their use,addressing the side effects caused by PPI overuse, and serving as a leading example forTCM clinical research. Lastly, the study aims to optimize the efficacy of Tongjianggranules and address potential safety concerns, such as diarrhea.