Effects of Moderate-intensity Interval Aerobic Exercise (MIIAE) on Inflammatory, Immune, Metabolic, Physical Fitness, and Quality of Life Parameters in Breast Cancer Patients Undergoing Radiotherapy

Breast cancer and its treatment with radiotherapy may be associated with systemicinflammatory, hematological, cardiac, body composition, functional and quality‐of‐lifealterations. Exercise has emerged as a non‐pharmacological strategy with potentialbenefits during oncological treatment; however, further evidence is needed regarding theeffects of supervised moderate‐intensity interval aerobic exercise during radiotherapy.This randomized controlled trial aims to evaluate the effects of a supervisedmoderate‐intensity interval aerobic exercise programme on systemic inflammatory andimmune‐derived hematological indices, cardiac biomarkers, body composition, musclestrength, lower‐limb power, sleep quality and breast cancer‐specific quality of life inwomen with breast cancer undergoing radiotherapy.Participants will be allocated to either an experimental group performing supervisedmoderate‐intensity interval aerobic exercise during radiotherapy or to a control groupreceiving usual care without structured exercise during the study period. Outcomes willbe assessed at baseline and after completion of the intervention period.