A randomized controlled trial of transcatheter arterial chemoembolization(TACE) in patients with advanced hepatocellular:Comparison of periodical TACE versus recurrence time TACE

INTERVENTION: TACE was underwent when the recurrence of HCC was observed via follow‐up dynamic CT or MRI. However, when no recurrence of HCC was observed, planned periodic TACE was repeated at 6 month intervals. TACE was repeated only when the recurrence of HCC was observed via follow‐up dynamic CT or MRI. CONDITION: advanced hepatocellular carcinoma(HCC) PRIMARY OUTCOME: cumulative survival rate INCLUSION CRITERIA: a)patients with untreated HCC not suitable for curative treatment b)Child A or B c)hypervascular tumor diagnosed via dynamic CT or MRI d)TNMStage 2‐3 e) PS 0‐2 f)serum creatinine level below 2mg/dl g)Age is within 20‐79 years old