The effect of honey in healing of 3rd and 4th degree burn wounds

INTERVENTION: Intervention 1: Irrigation of wound will be performed every 12 hours with normal saline and then wound will be covered and dressed with a layer of honey with a dose of 1 inches per 5 square centimeter of wound surface area. Treatment duration will take three weeks. Intervention 2: Irrigation of wound will be performed every 12 hours with normal saline and then wound will be covered and dressed with a layer of mefnaid acetate with a dose of 1 inche per 5 square centimeter of wound surface area. Treatment duration will take three weeks. Irrigation of wound will be performed every 12 hours with normal saline and then wound will be covered and dressed with a layer of honey with a dose of 1 inches per 5 square centimeter of wound surface area. Treatment duration will take three weeks. Irrigation of wound will be performed every 12 hours with normal saline and then wound will be covered and dressed with a layer of mefnaid acetate with a dose of 1 inche per 5 square centimeter of wound surface area. Treatment duration will take three weeks. CONDITION: Burn of third degree, body region unspecified Third‐degree burn NOS Burns. ; Burn of third degree, body region unspecified Third‐degree burn NOS PRIMARY OUTCOME: Area of granulation tissue. Timepoint: Before the intervention, one week, three weeks and one month after the intervention. Method of measurement: cm^2. SECONDARY OUTCOME: Scar. Timepoint: One week, three weeks, one month and six months after the intervention. Method of measurement: Visual analogue scale. Wound infection. Timepoint: One week, three weeks, one month and six months after the intervention. Method of measurement: Incidence of infection. INCLUSION CRITERIA: INCLUSION CRITERIA: presence of 3rd and 4th degree burn wounds Exclusion criteria: drug hypersensitivity, superficial burn wounds, involvement of more than over 20 percent of body surface area