Role of topical oxytocin in improving vaginal atrophy in postmenopausal women: A randomized controlled trial

INTERVENTION: Methyl Cellulose (Placebo) oxytocin vaginal gel CONDITION: ; post‐menopausal vaginal atrophy post‐menopausal vaginal atrophy PRIMARY OUTCOME: ¿ Histopathological evaluation of punch biopsy of the vaginal mucosa ¿ Visual and colposcopic changes in vaginal mucosa Symptoms (Dyspareunia & soreness) SECONDARY OUTCOME: ¿ Serum level of estradiol INCLUSION CRITERIA: ¿ Healthy postmenopausal women (at least two years after menopause) who were suffering from symptoms of vaginal atrophy (such as vaginal dryness, pain, itching, discomfort and bleeding during intercourse). ¿ Had not used any estrogen or other hormonal treatments (systemic or topical) during a four‐week period prior to the trial.