[Studying the development of imipramine tolerance and prospects of its overcoming with the aid of tianeptine].

Reaction of two groups of mice to sub-chronic imipramine administration has been studied in a series of experiments, where one (control) group received physiological saline instead of imipramine. Then, both groups were randomly divided to receive either tianeptine (two groups) or physiological saline (two groups) for three days. After this period, the reaction of mice to imipramine was assessed again by measuring the immobilization duration in the tail suspension test. It was found that sub-chronic administration of imipramine (6 days) did not reduce sensitivity of the mice to this medication. Tianeptine showed "pro-depressive" action in the tail suspension test, but the administration of tianeptine increased the sensitivity of rodents to imipramine.