Double-blind assessment of potential pergolide-induced cardiotoxicity.

Category Primary study
JournalNeurology
Year 1986
Possible pergolide-induced cardiotoxicity has been reported in open trials. Over a 6-month period of observation, we prospectively analyzed ECGs and 24-hour ambulatory ECG in 23 patients with Parkinson's disease who were randomized in a double-blind fashion to pergolide or placebo treatments. Pergolide therapy was associated with a mild and transient bradycardiac effect, but no clinically significant cardiotoxicity.
Epistemonikos ID: 0a9ee080e94635e1f1e59be1eba8dcd14c955da9
First added on: May 14, 2022