Treatment of Invasively Ventilated Adults With Early Activity and Mobilisation

The aim of this study is to evaluate the effect of early activity and mobilisation during prolonged IMV on the composite outcome \"days alive and out of hospital to day 180\". The effect of the intervention on mortality, physical, cognitive and psychological function at 180 days, as well as cost-effectiveness of the intervention, will also be evaluated. The study will also explore process of care measures and baseline physiology and ICU mobility outcomes. The hypothesis is that, in ICU patients expected to require prolonged IMV, early activity and mobilisation increases the number of days alive and at home to day 180 when compared with standard care.