A prospective randomised study conducted in an adult intensive care unit to compare the biochemical and acid-base effects of two solutions used during continuous renal replacement therapy (CRRT).

INTERVENTION: Continuous veno‐venous haemofiltration (CVVHF) using a new predilution haemofiltration solution containing 15mmol/L of trisodium citrate as the anticoagulant. CVVHF is conducted routinely in the Intensive Care Unit (ICU) when patients with critical illness require kidney support. The treatment regime lasts, on average, about five days though there is considerable variation in length of treatment. The patients are usually simultaneously undergoing some type of ventilatory support. Blood samples are routinely taken on at least a daily basis whilst the patients are receiving CVVHF. The occurrence of adverse events is monitored and if noted, dealt with in a timely and appropriate manner. CONDITION: Acute kidney failure PRIMARY OUTCOME: The difference in standard base excess between the two groups being studied. ; The SBE forms part of the normal blood gas report and the numerical result for the SBE was recorded from the serial arterial blood gas analyses taken as part of the routine care of all ICU patients. SECONDARY OUTCOME: Mortality rate between the two groups. ; This outcome was assessed by chart audit. INCLUSION CRITERIA: Non‐pregnant adult patients who require extracorporeal support for acute kidney failure while being treated in an intensive care unit (ICU).