Channel tropism of the prescription for kidney tonifying by target-oriented administration for osteoporosis

Objective: Targeting acupuncture administered by the efficacy of the treatment of osteoporosis and kidney herbs through clinical experimental observation , analysis of targeted drug delivery and Drug Meridian correlation methods :. ① observed object : Select 2004-08/2006-12 Hebei Medical University, Shijiazhuang osteoporosis specialist outpatient and hospital outpatient osteoporosis Qiaodong 180 patients ( patients with informed consent and approval by the Ethics Committee of the unit ) ② experimental groups : random number table 180 patients divided into six group: kidney prescription oral group , the group posted outside the kidney , bladder meridian group Ipriflavone group Gushukang group , and by the non- acupuncture group , 30 cases , with an average age of each group (60.5 ± 6.0) years old , average duration (6.32 ± 2.03) in group general information .6 no significant difference (P> 0.05), comparable. kidney herbs by the yellow, Epimedium , yams , Salvia , Drynaria , independent living and other drugs , each 5 pills containing raw herbs 3 g; anti- osteoporosis patch : the yellow, Epimedium , yams , Salvia , Drynaria , independent living and other drug composition ) ; By Michel labeled CTQ pharmaceutical Co., Ltd.; bone gushukang particles from the Rehmannia , epimedium , astragalus, salvia , Drynaria, mushrooms, cucumbers subcomponents ③ experimental intervention : kidney Recipe oral group : oral prescription 10 pills kidney / time, 3 times / d, for taking 6 . months posted outside the kidney acupuncture groups: Select kidney meridian original hole too big clock Creek and contact points ; bladder meridian acupuncture group : Select the bladder full sun and contact point back Shenshu flying ; externally bonded by non- non-acupoint group: Select thigh and back after no meridian wider area ; each acupoint sticking group 2 g crude drug , once every two days , alternating left and right Ipriflavone group: oral according to Pu . pull seal 200mg / time, 3 times / d Gushukang group : oral Gushukang particles 10 g / times, 2 times / d, each group are six month course of treatment , during treatment without any other TCM . anti-osteoporosis treatment ④ Evaluation: Compare 6 groups pain symptoms and bone mineral density , serum Ca, P, alkaline phosphatase, urinary hydroxyproline , parathyroid hormone , calcitonin, estradiol, . changes in testosterone and other indicators of the efficacy of a comprehensive evaluation , the evaluation criteria are divided into markedly effective, effective , ineffective results: 180 patients were included in the final analysis ① kidney prescription oral group , the group posted outside the kidney , bladder meridian group Ipriflavone group Gushukang group after treatment , increased bone density , estradiol , testosterone, calcitonin ; reduce parathyroid hormone ; total effective rates were 90.0% , 83.33% , 83.33% , 83.33% , 83.33% ② non- non-acupoint group after treatment , bone mineral density , estradiol , testosterone , calcitonin, the difference was not statistically significant (P> 0.05) before parathyroid hormone and treatment ; total effective rate of 46.67% Conclusion : targeting Meridian Meridian administration can significantly improve the regulation of kidney herbs , and at least two targets in the bone and gonadal work.