Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis Patients

The microbial profile shift that occurs during the transition from periodontal health togingivitis or periodontitis makes it clear that the initiation and progression ofperiodontal diseases depend totally upon the presence of a dental biofilm. This microbialshift provides the rationale for the main objective of periodontal therapy, which aims toconvert the biofilm from being associated with disease to being associated with health.Accordingly, the most effective therapies depend on relatively nonspecific approachesthat physically disrupt the biofilm and decrease the oral bacterial load (Craig, 2016).Using modified PRF with anti‐bacterial properties can be highly important as a topicalsurgical tool that promotes tissue healing and prevents local infection (Polak,Clemer‐Shamai and Shapira, 2019; El‐Sayed et al., 2026). Moreover, such application mayreduce the need for systemic antibiotic regimens (Polak, Clemer‐Shamai and Shapira,2019).More recently, a novel protocol termed minimally invasive nonsurgical therapy (MINST) hasbeen proposed for the treatment of isolated deep pockets associated with intrabonydefects. Treatment of deep periodontal pockets by means of MINST consists of carefulscaling and root debridement using special ultrasonic devices with delicate tips andoperating microscope under local anesthesia (Nibali et al., 2019).Since the incorporation of antiseptics into I‐PRF hasn't been tested clinically yet, thisstudy intends to evaluate the clinical and radiographic effects of using Chorhexidineaugmented injrctable‐platelet‐rich fibrin together minimally invasive non‐surgicalperiodontal therapy in the treatment stage III periodontitis patients.