Pain perception following subcutaneous injections of citrate-buffered and phosphate-buffered epoetin alpha.

Authors
Category Primary study
JournalThe International journal of artificial organs
Year 1998
Subcutaneous injection of citrate-buffered epoetin alpha (EPO-alpha) causes pain. Substitution of citrate buffer with a phosphate buffer in the EPO-alpha resulted in a significant reduction in duration and severity of pain. It is possible that sodium citrate which is present in the EPO-alpha may be the agent that causes discomfort in the patients.
Epistemonikos ID: 08a84ffbcd81bb274f2bdff2f3c19815ad4e658d
First added on: May 13, 2022