Effect of paracetamol versus paracetamol combined with pregabalin versus paracetamol combined with pregabalin and dexamethason on pain and opioid requirements in patients scheduled for abdominal hystrectomy.

INTERVENTION: Product Name: pregabalin Pharmaceutical Form: Capsule* Pharmaceutical form of the placebo: Capsule* Route of administration of the placebo: Oral use Product Name: Dexamethason Pharmaceutical Form: Intravenous infusion Pharmaceutical form of the placebo: Capsule* Route of administration of the placebo: Oral use CONDITION: Women scheduled for abdominal hysterectomy needs postoperative pain treatment, i.e. morphine. Morphine has side‐effects: nausea, vomiting, sedation and dizziness. These side‐effects are of course unpleasant for the patients and sometimes keep them in hospital for a longer time than needed. PRIMARY OUTCOME: Main Objective: To improve the postoperative pain treatment for patients with an abdominal hysterectomy, by using a new combination of secondary analgesics, and thereby hopefully minimizing there need for morphine postoperatively. Primary end point(s): The total amount of morphine needed postoperatively from 0 – 4 h, and 0 – 24 h, administered by patient controlled pain treatment. (PCA). Secondary Objective: To see if the well‐known analgesic effect of pregabalin, dexametason and paracetamol can act synergistically in patients who becomes an abdominal hysterectomy. INCLUSION CRITERIA: Women scheduled for abdominal hysterectomy, between the age of 18 and 75. ASA 1‐2; and with a BMI: between 18 and 32. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18‐64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range