Meta analysis of efficacy comparison of Compound Danshen Dropping Pills and isosorbide mononitrate in treatment for angina pectoris of coronary heart disease

AIM: To evaluate the clinical efficacy and safety of Compound Danshen Dropping Pills and isosorbide mononitrate in the treatment of angina pectoris of patients with coronary heart disease. METHODS: Published articles regarding the treatment of the above disease were collected by a thorough search of major database such as CNKI,VIP,CBM,PubMed,EMBase,Cochrane library(1990-2012).Data from seventeen articles were used in the current research.Among them,nine researches were based on medicine treatments of four weeks length and eight were based on medicine treatment of eight weeks length.There were five level C articles and twelve level B articles.Based on Juni evaluation system,meta analysis of the data was done by using the software RevMan 5.0. RESULTS: For treatment of four weeks length,the clinical effective rate of Compound Danshen Dropping Pills compared with isosorbide mononitrate was at OR=5.28,95%CI=(3.41,8.18),P0.05.Effective rate of electrocardiogram was at OR=2.75,95%CI=(1.92,3.93),P0.05.Incidence of adverse reactions was at OR=0.21,95%CI=(0.11,0.43),P0.05.For treatment of eight weeks length,the clinical effective rate was at OR=2.19,95%CI=(1.16,4.14),P0.05;Effective rate of electrocardiogram was at OR=1.68,95%CI=(1.22,2.30),P0.05.Incidence of adverse reactions was at OR=0.09,95%CI=(0.03,0.31),P0.05.Adverse reactions found were mainly palpitations,face flush,dizziness or headache.No serious adverse reactions were reported.All adverse reactions disappeared shortly after the discontinuation of treatment. CONCLUSION: According to the results,compared with isosorbide mononitrate,Compound Danshen Dropping Pills show advantages in instant effects,quick ease of symptoms and fewer adverse reactions.The research indicates that Compound Danshen Dropping Pills have more effect in the treatment of angina pectoris caused by coronary heart disease.