Human clinical trials to evaluate the efficacy and safety of Gynostemma pentaphyllum leaf extract for improving skin health (skin photoaging and skin hydration)

Authors
Category Primary study
Registry of TrialsKorean Clinical Trials Database
Year 2026
INTERVENTION: Dietary Supplement : Test: Gynostemma pentaphyllum leaf extract 340 mL/day (340 mL as the test ingredient Gynostemma pentaphyllum leaf extract), taken orally once daily, 1 bottle at a time Control: Placebo 340 mL/day (0 mL as the test ingredient), taken orally once daily, 1 bottle at a time CONDITION: Not Applicable PRIMARY OUTCOME: Crow's feet (Device evaluation) Skin elasticity skin moisturizing SECONDARY OUTCOME: Amount of dead skin cells Skin roughness Transepidermal water loss INCLUSION CRITERIA: 1. Men and women aged 25 to 60 at the time of screening 2. Individuals with a skin moisture content of 48 A.U. (Corneometer value) or lower and eye wrinkles of grade 3 or higher 3. Individuals who have received a detailed explanation of this clinical trial, fully understood it, voluntarily decided to participate, and provided written consent to comply with precautions during the trial period
Epistemonikos ID: 07f45014c0fe371894547c68ce4f0664bc9a2665
First added on: Oct 08, 2026