Evaluation of the efficacy of the formulation of topical anesthesia of Lidocaine / Articaine 4% and Lidocaine / Prilocaine 2.5% with and without Sodium Bicarbonate in the mucosa located posterior to upper canine teeth

INTERVENTION: A total of 42 volunteers, 21 men, and 21 women will be selected from undergraduate and postgraduate students of the Dentistry Department of the Federal University of Sergipe. It will be applied to the palatal mucosa region of right and left side canines 100mg (previously weighed) of the formulation selected by randomization of the application side of each formulation (Franz‐Montan et al., 2012). Laterality for application of the gels will be determined by prior randomization so that the applicator, the volunteer and the evaluator will not know which formulation will be used on each side of the application. Anesthesia, Local Carticaine Drug Lidocaine Other specified disorders of teeth and supporting structures Prilocaine Procedure/surgery CONDITION: Anxiety Disorders ; Organic anxiety disorder Organic anxiety disorder PRIMARY OUTCOME: All four groups of topical anesthetics present a latency time of fewer than 10 minutes and a duration of at least 10 minutes, verified through the dispositive, which contains calibrated filaments, mounted on supports and protected inside transparent tubes. The filaments are calibrated to undergo flexion with predetermined force.; We also hope that the four topical anesthetics present efficiency in the control of pain during local anesthesia, verified through the visual analog scale, The Visual Analog Scale (EAV) is a 10cm line with no numbers or demarcations except at the ends where there are 0 (zero) and 10 (ten) markings. Marking 0 corresponds to no pain, and marking 10 is the worst possible pain. The classification of the pain is made by placing a vertical mark on the line; the distance between the mark and the extremities 0 and 10 is measured by a millimeter ruler, evaluating the painful sensitivity of the volunteer (Jensen, Karoly, and Braver, 1986). SECONDARY OUTCOME: Secondary outcomes are not expected INCLUSION CRITERIA: Criteria for inclusion of volunteers in the research: age between 18‐35 years; ability to provide written consent; Undergraduate or graduate student of the dentistry department of the Federal University of Sergipe who has already undergone local anesthesia without intercurrences; Not having undergone anesthesia in the region in the two weeks prior to the study; Do not use medication that changes perception of pain in the 2 weeks prior to the study; Do not present systemic changes or a history of hypersensitivity to the drugs under study.