Clinical trial for development of topical rapamycin treatment for rosacea

INTERVENTION: The similar eruptions of rosacea on both sides of the face are chosen as the treatment lesions. 0.2% rapamycin ointment is applied on the skin lesion on the right, and the ointment base or the ointment base with lactose is applied on the similar skin lesion on the left twice a day for 8 weeks. The similar eruptions of rosacea on both sides of the face are chosen as the treatment lesions. 0.2% rapamycin ointment is applied on the skin lesion on the left, and the ointment base or the ointment base with lactose is applied on the similar skin lesion on the right twice a day for 8 weeks. CONDITION: rosacea PRIMARY OUTCOME: Changes in redness and size of eruptions after 4 and 8 weeks of treatment, and at 4 and 8 weeks after end of treatment SECONDARY OUTCOME: Appearance of contact dermatitis ; Rapamycin levels in whole blood ; histological findings in specimens of skin tissue in the cases who agree with skin biopsy INCLUSION CRITERIA: 1) Patients with rosacea who come to our outpatient department. 2) Patients who are resistant to previous treatment. 3) Patients who want to receive the treatment with the rapamycin ointment. 4) Patients who have not received topical steroid treatment for more than 2 months in the previous year.