A Study Comparing Virtual Reality-Based Interventions and conventional interventions for Clinical depression

Authors
Category Primary study
Registry of TrialsClinical Trials Registry - India
Year 2026
INTERVENTION: Intervention1: Virtual Reality Based Intervention: 3 parts‐ 1. Virtual reality based CBT 2. Virtual reality based mindfulness 3. Virtual reality based music therapy Control Intervention1: Conventional Interventions: 1. CBT 2. Mindfulness 3. Music Therapy CONDITION: Health Condition 1: F330‐ Major depressive disorder, recurrent, mild PRIMARY OUTCOME: 1. Automatic thoughts questionnaire‐negative (ATQ) ; 2. Beck Hopelessness Scale (BHS) ; 3. The Beck Depression Inventory‐II (BDI‐II) ; 4. Hamilton Depression Rating Scale (HDRS or HAM‐D) ; 5. The Difficulties in Emotion Regulation Scale Short Form ; 6. Behavioral activation for depression scale Short Form (BADS‐SF) ; 7. Social Interaction Anxiety Scale (SIAS) ; 8. Technostress Questionnaire ; 9. Cybersickness in Virtual Reality Questionnaire (CSQ‐VR, 2023) ; Timepoint: During baseline, after intervention (after 4 weeks of full treatment) SECONDARY OUTCOME: 1. Physiological Marker 1‐ Heart Rate Variability (HRV) ; 2. Physiological Marker‐ Blood PressureTimepoint: During baseline, after intervention (after 4 weeks of full treatment) INCLUSION CRITERIA: 1. Adults aged between 18 and 35 years. 2. Individuals exhibiting mild depressive symptoms, as indicated by standardized assessment tools such as the Beck Depression Inventory II (BDI‐II). 3. Adults with acute depression i.e. less than 6 months. 4. Participants who are not currently on psychiatric medication or has refused to take pharmaceutical treatment. 5. Individuals with normal or corrected‐to‐normal vision, to ensure optimal engagement with VR‐based interventions. 6. Participants who demonstrate a willingness to engage with virtual reality (VR) equipment and comply with study procedures. 7. Individuals who are able to comprehend study instructions and provide informed consent independently. 8. Participants with a primary diagnosis of depression, irrespective of its etiology (e.g., situational, reactive, biological, or psychosocial origins). 9. Participants who can read and understa
Epistemonikos ID: 06164bb1eb0948293cc151c4f29e965f69d385f7
First added on: Aug 08, 2026