Pharmacodynamic analysis of intravenous bolus Ciprofol for loss of consciousness in patients undergoing general anesthesia: a randomized, prospective, double-blind study

INTERVENTION: Group B: ciprofol 0.20 mg/kg:Single intravenous bolus of ciprofol 0.20mg/kg.;Group A: ciprofol 0.15 mg/kg:Single intravenous bolus of ciprofol 0.15 mg/kg.;Group F: ciprofol 0.40mg/kg:Single intravenous bolus of ciprofol 0.40mg/kg.;Group E: ciprofol 0.35mg/kg:Single intravenous bolus of ciprofol 0.35mg/kg.;Group D: ciprofol 0.30mg/kg:Single intravenous bolus of ciprofol 0.30 mg/kg.;Group C: ciprofol 0.25 mg/kg:Single intravenous bolus of ciprofol 0.25 mg/kg.; CONDITION: None PRIMARY OUTCOME: TIme to Loss of consciousness; SECONDARY OUTCOME: bispectral index, BIS;Heart rate;Time to Respiratory Depression;Mean arterial pressure; INCLUSION CRITERIA: 1.Age 18–80 years, regardless of sex. 2.American Society of Anesthesiologists (ASA) Physical Status Classification Class I–III. 3.Scheduled for elective surgery requiring induction of general anesthesia. 4.Sign a written informed consent form.