Meta Analysis on Clinical Efficacy and Safety of Needle Medicine in Treatment of Depression

Objective: Systematic evaluation of the efficacy and safety of needling combined with conventional medicine in the treatment of depression. Method: Computer retrieval of Pubmed, Embase, Cochrane Library, CBM, CNKI and WanFang Data by two evaluators independently retrieving a randomized controlled trial (RCT) of needling combined Chinese medicine for depression, manual examination Seau Grey literature and references for published research, retrieval time frame is from March 2018. After independently sifting through the test, extracting information and evaluating methodological quality, the Meta analysis was conducted using RevMan 5.3 software. Results: final inclusion in 21 studies of 451 subjects, Meta analysis results showed needling Combined Chinese Medicine Trial Group Efficacy Better Than Conventional Western Medicine Control Group: Total Efficiency [OR=2.95,95% CI (2.07,4.22)]; Z-tested, P=5.95, P≈ 0.00001, differences in efficacy of the trial group versus the control group were statistically significant .HAMD pre- and post score [OR=-3.11,95% CI (-3.51, -2.71)]; Z-tested, P=15.22, P/ 0.00001, the difference is statistically significant. Meta analysis of the incidence of adverse reactions showed [OR=0.07,95% CI (0.04,0.14)], Z=7.80, P≈ 0.00001, Conclusion: The results of this Meta analysis suggest that the combination of needling and Chinese medicine for depression has a better clinical treatment. effects, adverse reactions but because of the small and low quality of the sample included in the study, the above conclusions need to be confirmed by randomized controlled trials of high quality and large samples.