Comparative Efficacy of Propofol Lidocaine Mixture alone with Fentanyl Pretreatment and Ondansetron Pretreatment for Propofol Lidocaine Mixture to Reduce Propofol induced Pain On Injection: a Double-Blinded Randomized Controlled Trial

INTERVENTION: Experimental Drug,Experimental Drug,Experimental Drug Normal saline 2 ml is injected 3 minutes before propofol 180 mg mi Xtwo percent lidocaine 40 mg has injected a total of 8 ml via iv catheter no 20 at dorsum hand that connects with extension tube 18 inch and stopcock.,Fentanyl 1 mcg per kilogram, up to 2 ml with normal saline, used to inject 3 minutes before propofol 180 mg mi Xtwo percent lidocaine 40 mg has injected a total of 8 ml via iv catheter no 20 at dorsum hand that connects with extension tube 18 inch and stopcock.,Ondansetron 4 mg, 2 ml, used to inject 3 minutes before propofol 180 mg mi Xtwo percent lidocaine 40 mg has injected a total of 8 ml via iv catheter no 20 at dorsum hand that connects with extension tube 18 inch and stopcock. normal saline pretreatment for propofol lidocaine mixture ,fentanyl pretreatment for propofol lidocaine mixture ,Ondansetron pretreatment propofol lidocaine mixture CONDITION: Lidocaine, Fentanyl, Propofol, Ondansetron, Injection pain Patients undergoing general anesthesia. ; Lidocaine, Fentanyl, Propofol, Ondansetron, Injection pain PRIMARY OUTCOME: Verbal Numerical Rating Scale and Behavior pain scale are recorded immediately after the propofol injection immediately after the propofol injection Verbal Numerical Rating Scale and Behavior pain scale SECONDARY OUTCOME: incidence of adverse events; hypotension, bradycardia, and sedation. at 3 minutes after normal saline, fentanyl, ondansetron injection and 1 minute after propofol lidocaine mixture injection Patient reported outcome using a question. Clinical signs and hemodynamic changes were observed. INCLUSION CRITERIA: 1. Age 18 ‐ 65 years 2. Undergoing general anesthesia 3. Elective surgery 4. ASA physical status I or II