Investigating the effect of vitamin D on headache severity in adolescents

INTERVENTION: Intervention 1: The intervention group receives 1000 IU of Vitamin D supplement orally per day for 3 months. In addition, routine treatment including Propranolol tablets (20 mg every 12 hours) and Amitriptyline tablets (25 mg at night) is prescribed. Intervention 2: The control group receives only the routine treatment including Propranolol tablets (20 mg every 12 hours) and Amitriptyline tablets (25 mg at night) for 3 months and will not receive Vitamin D supplements. CONDITION: Migraine in children and adolescents. ; Migraine PRIMARY OUTCOME: Duration of headache in hours per day. Timepoint: Before intervention and one month after the intervention and two months after intervention and three months after the intervention. Method of measurement: Daily recording with timer. Headache intensity. Timepoint: Before intervention (Baseline), 1, 2, and 3 months after the start of interventio. Method of measurement: Visual analogue scale. Number of the patient’s headache attacks per month. Timepoint: Monthly. Method of measurement: Daily recording. Vitamin D. Timepoint: Before and after intervention. Method of measurement: Laboratory measurement of Vitamin D. INCLUSION CRITERIA: Adolescents aged between 10 and 18 years Definitive diagnosis of migraine by a pediatric neurologist based on ICHD‐3 criteria Serum vitamin D levels less than 30 ng/ml (deficiency or insufficiency) Willingness to participate and providing informed consent by parents or legal guardians Absence of chronic underlying diseases (cardiac, renal, or hepatic)