Nigella Sativa Amplifies Aerobic and Strength Training Effects on Metabolic, Inflammatory, and Oxidative Health in Type 2 Diabetes Patients

Background: Type 2 diabetes mellitus (T2DM) is a global health concern with high prevalence in developed countries. This study investigated the impact of giving Nigella sativa (NS) supplementation to combined aerobic-strength training (EX) on metabolic, inflammatory, and oxidative markers in T2DM.Methods: 90 middle-aged sedentary non-obese non-smoker males, clinically diagnosed with T2DM for approximately 10 years, were assigned to a 4-week randomaized controlled trial. Patients were randomly divided into 3 groups (n=30); aerobic and strength exercise (EX), EX+NS (2g-daily) and contro. Blood samples were collected pre-and post-interventions to examine the glycemic (Fructosamine and fasting blood glucose (FBG)), lipidimic (cholesterol, HDL, LDL, triglycerides), inflammatory (TNF-α, IL-4, Adiponectin) and oxidative (Thiobarbituric acid-reacting substances (TBARS), Catalase) profile of patients with T2DM.Results: This study revealed that a adding NS supplementation with aerobic and strength training demonstrates amplified benefits for type 2 diabetes patients, significantly improving glycemic control, lipid profiles, inflammatory markers, and oxidative stress parameters compared to exercise alone.Conclusion: These findings advocate integrating NS supplementation with structured exercise to enhance in T2DM management, offering a viable adjunct to conventional therapies.