Clinical Efficacy and Safety of Deep Brain Stimulation in the Treatment of Huntington disease: a randomized controlled trial

INTERVENTION: HD‐sham‐DBS group:sham‐DBS;HD‐DBS group:DBS; CONDITION: Huntington disease PRIMARY OUTCOME: UHDRS; SECONDARY OUTCOME: Mental Behavior Rating Scale;EQ‐5D;MRI data;LFP; INCLUSION CRITERIA: 1. Aged = 30 years; 2. 39 or more CAG repeats of HTT gene; 3. Meet HD diagnostic criteria based on genetic testing; 4. The major complaint is chorea; 5. Mini–Mental State Examination (MMSE) score > 25; 6. Unified Huntington's Disease Rating Scale (UHDRS) =20; 7. Before recruitment, stable medication having been used for at least 3 months, and no plan to change medication within 12 months after randomization; 8. Agree to be enrolled in this trial.