Efficacy of Homoeopathy as an add-on therapy to standard conventional treatment in schizophrenia patients

INTERVENTION: Intervention1: STANDARD THERAPY + homepathy medicines Homoeopathic medicines Antimonium crudum Apis mellifica Argentum nitricum Arsenicum album Aurum Metallicum Belladonna Bryonia alba Calcarea carbonica Calcarea phosphorica Causticum Chamomilla Cinchona officinalis Cocculus indicus Conium Maculatum Graphitis Gelsemium Glonoine Helleborus Niger Hepar Sulphur Hyoscyamus Niger Hypericum Perforatum Ignatia amara Kali Phosphoricum Lachesis Lycopodium clavatum Medorrhinum Mercurius solubilis Natrum muriaticum Natrum Sulphuratum Nitricum Acidum Nux moschata Nux vomica Phosphorus Phosphoric acid Pulsatilla nig. Psorinum Rhus toxicodendron Sepia Silicea Staphysagria Syphillinum Tabaccum Tarentula Cubensis Tarentula Hispana Thuja occidentalis Tuberculinum Veratrum album Zincum Metallicum: Indicated homeopathic medicine matching patients characterisitcs shall be given in four globules three to four times a day or three times a week , to be taken orally Control Intervention1: STANDARD THERAPY + Placebo: Identical placebo shall be given in four globules three to four times a day or three times a week , to be taken orally CONDITION: Schizophrenia PRIMARY OUTCOME: Change in symptom scores in comparison to Base line ‐ Positive and Negative Syndrome Scales (PANSS) and Clinical Global Impression (CGI‐SCH) rating scales at the exit of one year treatment.‐‐‐‐‐‐Timepoint: â?¢ Change in symptom scores in comparison to Base line ‐ Positive and Negative Syndrome Scales (PANSS) and Clinical Global Impression (CGI‐SCH) rating scales at the exit of one year and two year treatment. SECONDARY OUTCOME: â?¢WHO QOL‐BREF, SUBI at 1 & 2 year ; â?¢BPRS, HDRS & mGAF score at 1 and 2 year ; â?¢ homoeopathic medicines useful in management of predominant positive and negative symptoms of schizophrenia as sub groups. ; â?¢indications of the remedies . ; â?¢acute exacerbations in both the groups ; .the most effective medicines in acute exacerbations & characteristic indications . ; â?¢ most useful strategy of dose and repetition in acute exacerbations .‐‐‐‐‐‐Timepoint: 24 months INCLUSION CRITERIA: 1 Cases diagnosed as per ICD‐10 criteria for schizophrenia. 2 Age group 18‐45 yrs. of age. 3 Patients from both the sexes. 4 Cases from all socio‐economic background. 5 Those who sign written informed consent