Behandeling met radioactief jodium versus hemithyreoïdectomie, welke behandeling heeft het beste effect heeft op klachten bij patiënten met symptomatisch euthyreoot struma

INTERVENTION: Radioactive iodine treatment Hemithyroidectomy CONDITION: Euthyroidism, Radioactive iodine, Goiter, Benign euthyroid goitre ; ; PRIMARY OUTCOME: reduction of symptoms 12 months after treatment measured with ThyPro Questionnaire SECONDARY OUTCOME: ‐ Quality of life measured by EQ‐5D‐5L questionnaire after 6 months and 1‐5 years ; ; ‐ Voice impairment after 6 months and 1‐5 years as measured by the Voice Handicap ; Index, a specific questionnaire for voice impairment detection a ; ; ‐ Effect of treatment on symptoms after 6 months, 2, 3, 4 and 5 years after treatment ; as measurd by the ThyPRO questionnairre ; ; ‐ Goitre volume as measured on a CT‐scan 12 months after treatment ; ; ‐ Serum TSH, T4 levels, PTH (standard 2‐6 weeks after treatment or if measured under ; routine care at any time during follow‐up) ; ; ‐ Hypo‐ or hyperthyroidism ; ; ‐ Peri‐operative complications: vocal cords palsy ; ; ‐ Complications of radioactive iodine INCLUSION CRITERIA: ‐ Patients with symptomatic goitre ‐ Goitre size larger than 40 ml on one side determined on CT ‐ Patients accept both treatment modalities ‐ TSH between 0,5‐5,0 mE/L (euthyroidism) without Thyroid suppletion ‐ Not pregnant or childwish within 6 months after treatment ‐ Able to undergo surgery as well as radioiodine treatment ‐ 18 years or older