The effect of casein phosphopeptide - amorphous calcium phosphate on saliva

Authors
Category Primary study
Registry of TrialsISRCTN registry
Year 2022
INTERVENTION: Participants will be allocated equally into two groups: Group 1 (intervention) receive GC Tooth Mousse (CPP‐ACP) and Group 2 (control) receive a placebo mousse. A random allocation list will be carried out using the website https://www.randomlists.com/, all of the participants will be numbered from 1 ‐ 50 in order to allocate them randomly into the two study groups. Saliva samples are taken from the participants before the application, after the application directly, after half an hour and after an hour. the pH of the collected samples, salivary flow rate and calcium concentration are tested. CONDITION: Remineralization capacity of CPP‐ACP ; Oral Health PRIMARY OUTCOME: ; Measured at T0: before the application (baseline); T1: directly after the application ; T2: after half an hour; T3: after 1 hour:; 1. pH of saliva measured using pH test strips (Whatman® Panpeha™ pH indicator strips); 2. Salivary flow rate measured by calculating the amount of saliva which will be collected in tubes and dividing it into five to see the amount of saliva secreted per minute (ml/d); SECONDARY OUTCOME: Calcium concentration of saliva measured using Calein as an indicator, ethylenediaminetetra‐acetate (EDTA) as a Ca‐complexing agent, and a standard Ca solution to set up the calibration series; measured at T0: before the application (baseline); T1: directly after the application ; T2: after half an hour; T3: after 1 hour. INCLUSION CRITERIA: 1. Good oral hygiene 2. Participants not be taking antibiotics or any kind of medications that can affect the flow rate of saliva 3. Does not suffer from an allergy to milk protein confirmed or suspected and/or the presence of the sensitivity of benzoate (preservative)
Epistemonikos ID: 029feb85627d965cebd1fed54a1d63f02f7a2917
First added on: Aug 26, 2024