Reduction of low birth weight at delivery through the adjunction of oral azithromycin to the intermittent preventive treatment of malaria in pregnant women: a randomized controlled trial in rural Burkina Faso

INTERVENTION: Azithromicyn Sulfadoxine pyrimethamine CONDITION: ; Malaria ; Neonatal Diseases ; Pregnancy and Childbirth Malaria Neonatal Diseases Pregnancy and Childbirth PRIMARY OUTCOME: Proportion of low birth weight (birth weight < 2500 g) SECONDARY OUTCOME: Incidence of maternal Chlamydia trachomatis, Neisseria gonorrhoea, and vaginal Treponema pallidum infection Mean birth weight Mean duration of gestation Mean maternal blood hemoglobin concentration at selection and delivery Mean neonate weight gain Mean number of maternal illness days during pregnancy and during neonate follow up period Mean number of neonate illness days Number of serious and any adverse events Percentage of acute neonate distress Percentage of low chest circumference at birth Percentage of low chest or head circumference at birth Percentage of preterm delivered babies Percentage of women with mild, moderate or severe anemia at each point of hemoglobin assessment Percentage of women with peripheral blood malaria parasitaemia and mean parasite density at each month Prevalence of antibiotics resistant sexually transmitted infection Prevalence of maternal Chlamydia trachomatis, Neisseria gonorrhoea, and Treponema pallidum infection Rate of miscarriage Rate of stillbirth INCLUSION CRITERIA: 1. Being a pregnant woman between 16 and 32 weeks of pregnancy 2. At least 15 years old; and under 44 years old 3. Residence within the health facility catchment’s area, 4. Willingness to deliver at the health facility; 5. Willingness to adhere to the study protocol requirements; 6. Ability to provide written informed consent.