Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting.

Tested dronabinol (DAB) and prochlorperazine (PCZ) alone and in combination in a randomized, double-blind, parallel group, multicenter study. 62 patients (aged 20–68 yrs) were randomized to receive either (1) DAB 10 mg every 6 hrs plus placebo; (2) placebo plus PCZ 10 mg every 6 hrs; or (3) DAB and PCZ, each 10 mg every 6 hrs. Antiemetic treatment was begun 24 hrs before and continued for 24 hrs after the last dose of chemotherapy. Results confirm that patients respond better to a combination of DAB and PCZ than to PCZ alone. The combination was an effective antiemetic regimen when given with a variety of commonly used chemotherapeutic drugs. (PsycINFO Database Record (c) 2018 APA, all rights reserved)