A reassessment of the mechanism of action of 4'-[(9-acridinyl)-amino]methanesulphon-m-anisidide.

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Authors
Category Primary study
JournalEuropean journal of cancer & clinical oncology
Year 1982
The conclusion that treating cells with 4'-[(9-acridinyl)- amino]methanesulphon-m-anisidide (mAMSA) causes an alkali-dependent decrease in the size of their DNA was reinvestigated. Evidence is presented that alkali is not needed to detect an effect of mAMSA on the sedimentation rate of DNA released from mAMSA-treated PY815 cells and that mAMSA causes double-strand breaks in cellular DNA.
Epistemonikos ID: 3631409ab7cce5cb119106b5b371a9551da783f1
First added on: Apr 19, 2022