The expression and mutation of BRCA1/2 genes in ovarian cancer: a global systematic study.

INTRODUCTION: This systematic review was designed to summarize the findings on the expression and mutation of BRCA1/2 genes in ovarian cancer (OC) patients, focusing on mutation detection technology and taking clinical decisions for better treatment. AREAS COVERED: We conducted a systematic review by following the PRISMA document selection guidelines for the document selection process and the PICOT standard for developing the keyword to search for. Total 5729 publications were included, and 50 articles were put into the final screening. The results showed that NGS was a breakthrough technology in detecting BRCA1/2 gene mutations because of its efficacy and affordability. Other technologies are also being applied now for mutation detection. The most prominent association of BRCA1/2 gene mutations was age, heredity, and family history. Furthermore, mutations of BRCA1/2 could improve survival rate and overall survival. There is no sufficient study available to conclude a systematic analysis for the expression of BRCA1/2 gene in OC. EXPERT OPINION: Research will continue to develop more diagnostic techniques based on the expression and mutation of BCRA1/2 genes for OC in the near future.